mca Syllabus

Bio Informatics
Code : CS 704B
Credits: 3
Module I: 12L

Introduction to Genomic data and Data Organization: Sequence Data Banks - Introduction to sequence date banks - protein sequence data bank. NBFR-PIR, SWISSPROT, Signal peptide data bank, Nucleic acid sequence data bank - GenBank, EMBL nucleotide sequence data bank, AIDS virus sequence data bank. RRNA data bank, structural data banks - protein Data Bank (PDB), The Cambridge Structural Database (CSD) : Genome data bank - Metabolic pathway data : Microbial and Cellular Data Banks.

Module II: 12L
Introduction to MSDN (Microbial Strain Data Network): Numerical Coding Systems of Microbes, Hibridoma Data Bank Structure, Virus Information System Cell line information system; other important Data banks in the area of Biotechnology/life sciences/biodiversity. Sequence analysis: Analysis Tools for Sequence Data Banks; Pair wise alignment -NEEDLEMAN and Wunsch algorithm, Smith Waterman, BLAST, FASTA algorithms to analyze sequence data: Sequence patterns motifs and profiles.

Module III: 11L
Secondary Structure predictions; prediction algorithms; Chao-Fasman algorithm, Hidden-Markov model, Neural Networking. Tertiary Structure predictions; prediction algorithms; Chao-Fasman algorithm, Hidden-Markov model, Neural Networking.

Module IV: 10L
Applications in Biotechnology: Protein classifications, Fold libraries, Protein structure prediction: Fold recognition (threading), Protein structure predictions : Comparative modeling (Homology), Advanced topics: Protein folding, Protein-ligand interactions, Molecular Modeling & Dynamics, Drug Designing.

Books:
1. Lesk, Introduction to Bio Informatics, OUP
2. Introduction to Bioinformatics, Atwood, Pearson Education
3. Developing Bioinformatics Computer Skills, Cynthia Gibas and Per Jambeck, 2001 SPD
4. Statistical Methods in Bioinformatics, Springer India
5. Beginning Perl for Bio-informatics, Tisdall, SPD
6. Biocomputing: Informatics and Genome Project, Smith, D.W., 1994, Academic Press, NY
7. Bioinformatics: A practical Guide to the Analysis of Genes and Proteins, Baxevanis, A.D., Quellette, B.F.F.,
John Wiely & Sons.